Phone: (215) 898-6576
Fax: (215) 898-3695
E-Mail: malamud@pobox.upenn.edu
Position: Professor Appointed: 1984
Membership:
Research:
My general area of research involves the identification and characterization of anti-bacterial and anti-viral molecules.
Current research projects include:
Study of a member of the innate immune system, present in human saliva, that
inhibits HIV infectivity. The mechanism of action involves binding
of the glycoprotein, gp340, to gp120 on the virion.
Development of assays utilizing oral fluid as non-invasive diagnostics. Currently we are designing a novel point detection system for identification of bacterial and viral pathogens.
Identification and development of novel microbicidal agents to prevent the sexual transmission of HIV and other STDs.
Patents:
Method for inactivating enveloped viruses and sperm, U.S. Patent No. 5,314,917 (Issued 5/24/94)
Remote Controlled System for Drug Delivery, U.S. Patent No. 5,928,195
(Issued 7/27/99)
Method for inactivating sexually transmitted viruses, U.S. Patent No. 6,297,278
(Issued 10/2/01)
Composition and methods useful in treatment and prevention of HIV-1 infection,
U.S. Patent No. 6,287,605 (Issued 9/11/01)
Representative Publications:
1. Wu, Z, Van Ryk, D., Davis, C., Abrams,
W.R., Chaiken, I., Magnani, J., and Malamud, D. 2003. Salivary
agglutinin inhibits HIV Type 1 infectivity through interaction with viral
glycoprotein 120.
AIDS Res and Human Retroviruses 19: 201-209.
2. Burrano, B.T., Schnaare, R.L., and Malamud,
D. Synthetic cervical mucus formulation. 2002. Contraception
66:137-140.
3. Barnhart, K., Pretorius S.E., Stolpen, A. and Malamud,
D. 2001. Distribution of topical medication in the human vagina
as imaged by MRI. 2001. Fertility and Sterility 76:189-195.
4. Nagashunmugam, T., Malamud, D., Davis, C., Abrams,
W.R., and Friedman, H.M. 1998. Human submandibular saliva inhibits
Human immunodeficiency virus Type 1 infection by displacing envelope
glycoprotein from the virus. J.
Infectious Disease 178:1635-1641.
5. Taichman, N.S., Cruchley, A.T., Fletcher, L.M.,
Hagi-pavli, E.P., Paleolog, E.M., Abrams, W.R., Booth, V., Edwards, R.M.,
and Malamud, D. 1998. Vascular endothelial growth factor in nuormal
human salivary glands
and saliva: A possible role in the maintenance of mucosal homeostasis.
Lab Invest. 78:869-875.
6. Malamud, D. and Tabak, L., Editors, Saliva
as a diagnostic fluid. Annals of the New York Academy of Sciences,
Volume 694, 1993.
7. Demuth, D.R., Golub, E.E., and MALAMUD,
D. 1990. Streptococcal-host interactions: Structural and functional analysis
of a S. sanguis receptor for a human salivary glycoprotein. J. Biol. Chem.
256:7120-7126.